Gene name:
IGSF1 (IGDC1;KIAA0364;PGSF2) ;
Protein name:
Immunoglobulin superfamily member 1 (IgSF1) ;
Alternative:
Inhibin-binding protein (InhBP) ;Immunoglobulin-like domain-containing protein 1 ;p120 ;Pituitary gland-specific factor 2 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with INHA (By similarity). In PubMed:12385827 does not interact with INHA; standard receptor binding assay. Interacts with ACVR1B; the interaction appears to be ligand-dependent as it is diminished by inhibin B and activin A. Interacts with ACVR2A, ACVR2B, ACVRL1 and BMPR1B. Interacts with HECTD1.
Function:
Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription.
Subcellular Location:
Isoform 3
Secreted
Protein Attributes:
50:
MTLDRPGEGA | TMLKTFTVLL | FCIRMSLGMT | SIVMDPQPEL | WIESNYPQAP |
100:
WENITLWCRS | PSRISSKFLL | LKDKTQMTWI | RPSHKTFQVS | FLIGALTESN |
150:
AGLYRCCYWK | ETGWSKPSKV | LELEAPGQLP | KPIFWIQAET | PALPGCNVNI |
200:
LCHGWLQDLV | FMLFKEGYAE | PVDYQVPTGT | MAIFSIDNLT | PEDEGVYICR |
250:
THIQMLPTLW | SEPSNPLKLV | VAGLYPKPTL | TAHPGPIMAP | GESLNLRCQG |
300:
PIYGMTFALM | RVEDLEKSFY | HKKTIKNEAN | FFFQSLKIQD | TGHYLCFYYD |
350:
ASYRGSLLSD | VLKIWVTDTF | PKTWLLARPS | AVVQMGQNVS | LRCRGPVDGV |
400:
GLALYKKGED | KPLQFLDATS | IDDNTSFFLN | NVTYSDTGIY | SCHYLLTWKT |
450:
SIRMPSHNTV | ELMVVDKPPK | PSLSAWPSTV | FKLGKAITLQ | CRVSHPVLEF |
500:
SLEWEERETF | QKFSVNGDFI | ISNVDGKGTG | TYSCSYRVET | HPNIWSHRSE |
550:
PLKLMGPAGY | LTWNYVLNEA | IRLSLIMQLV | ALLLVVLWIR | WKCRRLRIRE |
600:
AWLLGTAQGV | TMLFIVTALL | CCGLCNGVLI | EETEIVMPTP | KPELWAETNF |
650:
PLAPWKNLTL | WCRSPSGSTK | EFVLLKDGTG | WIATRPASEQ | VRAAFPLGAL |
700:
TQSHTGSYHC | HSWEEMAVSE | PSEALELVGT | DILPKPVISA | SPTIRGQELQ |
750:
LRCKGWLAGM | GFALYKEGEQ | EPVQQLGAVG | REAFFTIQRM | EDKDEGNYSC |
800:
RTHTEKRPFK | WSEPSEPLEL | VIKEMYPKPF | FKTWASPVVT | PGARVTFNCS |
850:
TPHQHMSFIL | YKDGSEIASS | DRSWASPGAS | AAHFLIISVG | IGDGGNYSCR |
900:
YYDFSIWSEP | SDPVELVVTE | FYPKPTLLAQ | PGPVVFPGKS | VILRCQGTFQ |
950:
GMRFALLQEG | AHVPLQFRSV | SGNSADFLLH | TVGAEDSGNY | SCIYYETTMS |
1000:
NRGSYLSMPL | MIWVTDTFPK | PWLFAEPSSV | VPMGQNVTLW | CRGPVHGVGY |
1050:
ILHKEGEATS | MQLWGSTSND | GAFPITNISG | TSMGRYSCCY | HPDWTSSIKI |
1100:
QPSNTLELLV | TGLLPKPSLL | AQPGPMVAPG | ENMTLQCQGE | LPDSTFVLLK |
1150:
EGAQEPLEQQ | RPSGYRADFW | MPAVRGEDSG | IYSCVYYLDS | TPFAASNHSD |
1200:
SLEIWVTDKP | PKPSLSAWPS | TMFKLGKDIT | LQCRGPLPGV | EFVLEHDGEE |
1250:
APQQFSEDGD | FVINNVEGKG | IGNYSCSYRL | QAYPDIWSEP | SDPLELVGAA |
1300:
GPVAQECTVG | NIVRSSLIVV | VVVALGVVLA | IEWKKWPRLR | TRGSETDGRD |
1336:
QTIALEECNQ | EGEPGTPANS | PSSTSQRISV | ELPVPI
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Human IgSF1
ELISA Kit for Human IgSF1
ELISA Kit for Human IgSF1
Polyclonal Antibody for Human IgSF1
Polyclonal Antibody for Human IgSF1
Polyclonal Antibody for Human IgSF1
Monoclonal Antibody for Human IgSF1
Monoclonal Antibody for Human IgSF1
Monoclonal Antibody for Human IgSF1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);TISSUE SPECIFICITY
tissue :
Pituitary .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Brain .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
tissue :
Liver .
6.
"The DNA sequence of the human X chromosome."
Ross M.T.
,
Grafham D.V.
,
Coffey A.J.
,
Scherer S.
,
McLay K.
,
Muzny D.
,
Platzer M.
,
Howell G.R.
,
Burrows C.
,
Bird C.P.
,
Frankish A.
,
Lovell F.L.
,
Howe K.L.
,
Ashurst J.L.
,
Fulton R.S.
,
Sudbrak R.
,
Wen G.
,
Jones M.C.
,
Hurles M.E.
,
Andrews T.D.
,
Scott C.E.
,
Searle S.
,
Ramser J.
,
Whittaker A.
,
Deadman R.
,
Carter N.P.
,
Hunt S.E.
,
Chen R.
,
Cree A.
,
Gunaratne P.
,
Havlak P.
,
Hodgson A.
,
Metzker M.L.
,
Richards S.
,
Scott G.
,
Steffen D.
,
Sodergren E.
,
Wheeler D.A.
,
Worley K.C.
,
Ainscough R.
,
Ambrose K.D.
,
Ansari-Lari M.A.
,
Aradhya S.
,
Ashwell R.I.
,
Babbage A.K.
,
Bagguley C.L.
,
Ballabio A.
,
Banerjee R.
,
Barker G.E.
,
Barlow K.F.
,
Barrett I.P.
,
Bates K.N.
,
Beare D.M.
,
Beasley H.
,
Beasley O.
,
Beck A.
,
Bethel G.
,
Blechschmidt K.
,
Brady N.
,
Bray-Allen S.
,
Bridgeman A.M.
,
Brown A.J.
,
Brown M.J.
,
Bonnin D.
,
Bruford E.A.
,
Buhay C.
,
Burch P.
,
Burford D.
,
Burgess J.
,
Burrill W.
,
Burton J.
,
Bye J.M.
,
Carder C.
,
Carrel L.
,
Chako J.
,
Chapman J.C.
,
Chavez D.
,
Chen E.
,
Chen G.
,
Chen Y.
,
Chen Z.
,
Chinault C.
,
Ciccodicola A.
,
Clark S.Y.
,
Clarke G.
,
Clee C.M.
,
Clegg S.
,
Clerc-Blankenburg K.
,
Clifford K.
,
Cobley V.
,
Cole C.G.
,
Conquer J.S.
,
Corby N.
,
Connor R.E.
,
David R.
,
Davies J.
,
Davis C.
,
Davis J.
,
Delgado O.
,
Deshazo D.
,
Dhami P.
,
Ding Y.
,
Dinh H.
,
Dodsworth S.
,
Draper H.
,
Dugan-Rocha S.
,
Dunham A.
,
Dunn M.
,
Durbin K.J.
,
Dutta I.
,
Eades T.
,
Ellwood M.
,
Emery-Cohen A.
,
Errington H.
,
Evans K.L.
,
Faulkner L.
,
Francis F.
,
Frankland J.
,
Fraser A.E.
,
Galgoczy P.
,
Gilbert J.
,
Gill R.
,
Gloeckner G.
,
Gregory S.G.
,
Gribble S.
,
Griffiths C.
,
Grocock R.
,
Gu Y.
,
Gwilliam R.
,
Hamilton C.
,
Hart E.A.
,
Hawes A.
,
Heath P.D.
,
Heitmann K.
,
Hennig S.
,
Hernandez J.
,
Hinzmann B.
,
Ho S.
,
Hoffs M.
,
Howden P.J.
,
Huckle E.J.
,
Hume J.
,
Hunt P.J.
,
Hunt A.R.
,
Isherwood J.
,
Jacob L.
,
Johnson D.
,
Jones S.
,
de Jong P.J.
,
Joseph S.S.
,
Keenan S.
,
Kelly S.
,
Kershaw J.K.
,
Khan Z.
,
Kioschis P.
,
Klages S.
,
Knights A.J.
,
Kosiura A.
,
Kovar-Smith C.
,
Laird G.K.
,
Langford C.
,
Lawlor S.
,
Leversha M.
,
Lewis L.
,
Liu W.
,
Lloyd C.
,
Lloyd D.M.
,
Loulseged H.
,
Loveland J.E.
,
Lovell J.D.
,
Lozado R.
,
Lu J.
,
Lyne R.
,
Ma J.
,
Maheshwari M.
,
Matthews L.H.
,
McDowall J.
,
McLaren S.
,
McMurray A.
,
Meidl P.
,
Meitinger T.
,
Milne S.
,
Miner G.
,
Mistry S.L.
,
Morgan M.
,
Morris S.
,
Mueller I.
,
Mullikin J.C.
,
Nguyen N.
,
Nordsiek G.
,
Nyakatura G.
,
O'dell C.N.
,
Okwuonu G.
,
Palmer S.
,
Pandian R.
,
Parker D.
,
Parrish J.
,
Pasternak S.
,
Patel D.
,
Pearce A.V.
,
Pearson D.M.
,
Pelan S.E.
,
Perez L.
,
Porter K.M.
,
Ramsey Y.
,
Reichwald K.
,
Rhodes S.
,
Ridler K.A.
,
Schlessinger D.
,
Schueler M.G.
,
Sehra H.K.
,
Shaw-Smith C.
,
Shen H.
,
Sheridan E.M.
,
Shownkeen R.
,
Skuce C.D.
,
Smith M.L.
,
Sotheran E.C.
,
Steingruber H.E.
,
Steward C.A.
,
Storey R.
,
Swann R.M.
,
Swarbreck D.
,
Tabor P.E.
,
Taudien S.
,
Taylor T.
,
Teague B.
,
Thomas K.
,
Thorpe A.
,
Timms K.
,
Tracey A.
,
Trevanion S.
,
Tromans A.C.
,
d'Urso M.
,
Verduzco D.
,
Villasana D.
,
Waldron L.
,
Wall M.
,
Wang Q.
,
Warren J.
,
Warry G.L.
,
Wei X.
,
West A.
,
Whitehead S.L.
,
Whiteley M.N.
,
Wilkinson J.E.
,
Willey D.L.
,
Williams G.
,
Williams L.
,
Williamson A.
,
Williamson H.
,
Wilming L.
,
Woodmansey R.L.
,
Wray P.W.
,
Yen J.
,
Zhang J.
,
Zhou J.
,
Zoghbi H.
,
Zorilla S.
,
Buck D.
,
Reinhardt R.
,
Poustka A.
,
Rosenthal A.
,
Lehrach H.
,
Meindl A.
,
Minx P.J.
,
Hillier L.W.
,
Willard H.F.
,
Wilson R.K.
,
Waterston R.H.
,
Rice C.M.
,
Vaudin M.
,
Coulson A.
,
Nelson D.L.
,
Weinstock G.
,
Sulston J.E.
,
Durbin R.M.
,
Hubbard T.
,
Gibbs R.A.
,
Beck S.
,
Rogers J.
,
Bentley D.R.
more...
Nature434:325-337(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
"The full-ORF clone resource of the German cDNA consortium."
Bechtel S.
,
Rosenfelder H.
,
Duda A.
,
Schmidt C.P.
,
Ernst U.
,
Wellenreuther R.
,
Mehrle A.
,
Schuster C.
,
Bahr A.
,
Bloecker H.
,
Heubner D.
,
Hoerlein A.
,
Michel G.
,
Wedler H.
,
Koehrer K.
,
Ottenwaelder B.
,
Poustka A.
,
Wiemann S.
,
Schupp I.
more...
BMC Genomics8:399-399(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1153-1336
tissue :
Testis .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH ACVR1B; ACVR2A; ACVR2B; ACVRL1 AND BMPR1B
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HECTD1
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NEGATIVE INTERACTION WITH INHA
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.
"Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement."
Sun Y.
,
Bak B.
,
Schoenmakers N.
,
van Trotsenburg A.S.
,
Oostdijk W.
,
Voshol P.
,
Cambridge E.
,
White J.K.
,
le Tissier P.
,
Gharavy S.N.
,
Martinez-Barbera J.P.
,
Stokvis-Brantsma W.H.
,
Vulsma T.
,
Kempers M.J.
,
Persani L.
,
Campi I.
,
Bonomi M.
,
Beck-Peccoz P.
,
Zhu H.
,
Davis T.M.
,
Hokken-Koelega A.C.
,
Del Blanco D.G.
,
Rangasami J.J.
,
Ruivenkamp C.A.
,
Laros J.F.
,
Kriek M.
,
Kant S.G.
,
Bosch C.A.
,
Biermasz N.R.
,
Appelman-Dijkstra N.M.
,
Corssmit E.P.
,
Hovens G.C.
,
Pereira A.M.
,
den Dunnen J.T.
,
Wade M.G.
,
Breuning M.H.
,
Hennekam R.C.
,
Chatterjee K.
,
Dattani M.T.
,
Wit J.M.
,
Bernard D.J.
more...
Nat. Genet.44:1375-1381(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DEVELOPMENTAL STAGE;TISSUE SPECIFICITY;VARIANTS CHTE 708-ALA--LYS-716 DEL; ASN-765; PHE-858 AND ARG-942;CHARACTERIZATION OF 708-ALA--LYS-716 DEL; ASN-765; PHE-858 AND ARG-942